When pharmaceutical and medical device manufacturers run into headaches, they often call Reed Smith.

The firm’s national products liability practice, largely led by California-based partners, represents companies such as Merck, Medtronic and GlaxoSmithKline. Medtronic turned to Reed Smith after it was hit with hundreds of suits alleging problems with off-label use of a bond graft fusion device designed for degenerative disc disease. Reed Smith L.A. partners Michael Brown and Lisa Baird have shut down many of the claims by asserting federal preemption.